Name | 2-Bromo-4-(2-methyl-2-propanyl)-1-nitrobenzene |
Synonyms | 2-Bromo-4-(2-methyl-2-propanyl)-1-nitrobenzene Benzene, 2-bromo-4-(1,1-dimethylethyl)-1-nitro- |
CAS | 860687-69-0 |
Molecular Formula | C10H12BrNO2 |
Molar Mass | 258.11 |
Density | 1.401±0.06 g/cm3(Predicted) |
Boling Point | 142-144 °C |
application | 2-bromo-4-(1, 1-dimethylethyl)-1-nitrobenzene can be used as organic synthesis intermediates and pharmaceutical intermediates, used in laboratory research and development processes and chemical production processes. |
preparation | add 20mL 95% concentrated sulfuric acid into a 50ml three-mouth bottle, magnetic stirring, cooling in an ice bath below 0 ℃, adding 1-bromo -3-(1, 1-dimethylethyl) benzene, stirring until it is completely dissolved, and then continue stirring for 20 minutes, then slowly drop 95% fuming nitric acid within 1 hour. After dropping, the reaction was stirred at low temperature for 30min. Slowly pour the reaction solution into ice water under stirring. Precipitation of white solids. The filter cake was washed to neutral with 5% sodium bicarbonate aqueous solution and water respectively, and the obtained solid was recrystallized with 80% ethanol/aqueous solution and dried at 60 ℃. TLC is shown as single-dot (spreading agent: petroleum ether/ethyl acetate = 3:l,v/v). 2-Bromo-4-(1, 1-dimethylethyl)-1-nitrobenzene. |